Meet our team.
Victoria Marshe, HBSc
PhD Candidate
Institute of Medical Science | University of Toronto
Fellow, Strategic Training for Advanced Genetic Epidemiology | CANSSI
Victoria Marshe is a PhD candidate under the co-supervision of Drs. Daniel Mueller and Sidney Kennedy at the Institute of Medical Science and the Pharmacogenetics Research Clinic at the Centre for Addiction and Mental Health (CAMH). Her research focuses on understanding the genetic contributions to antidepressant non-remission in older adults with late-life depression, which is characterized by a pathophysiology associated with underlying cerebrovascular and neurodegenerative changes. Currently, Victoria is focusing on understanding the methodological opportunities and challenges for machine learning associated with the integration of genome-wide data from large-scale, epidemiological datasets and smaller, clinical-treatment cohorts.
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Victoria’s Projects
Predicting Response to Antidepressants
Late-Life Depression
Selected Publications
Pharmacogenetic Implications for Antidepressant Pharmacotherapy in Late-Life Depression: A Systematic Review of the Literature for Response, Pharmacokinetics and Adverse Drug Reactions.
Marshe VS, Islam F, Maciukiewicz M, Bousman C, Eyre HA, Lavretsky H, Mulsant BH, Reynolds CF 3rd, Lenze EJ, Müller DJ. Am J Geriatr Psychiatry. 2020 Jun;28(6):609-629.
Validation study of microRNAs previously associated with antidepressant response in older adults treated for late-life depression with venlafaxine.
Marshe VS, Islam F, Maciukiewicz M, Fiori LM, Yerko V, Yang J, Turecki G, Foster JA, Kennedy SH, Blumberger DM, Karp JF, Kennedy JL, Mulsant BH, Reynolds CF 3rd, Lenze EJ, Müller DJ. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jun 8;100:109867.
Investigation of the Gut Microbiome in Patients with Schizophrenia and Clozapine-Induced Weight Gain: Protocol and Clinical Characteristics of First Patient Cohorts.
Gorbovskaya I, Kanji S, Liu JCW, MacKenzie NE, Agarwal SM, Marshe VS, Sriretnakumar V, Verdu EF, Bercik P, De Palma G, Hahn MK, Müller DJ. Neuropsychobiology. 2020;79(1):5-12.
Clinical implications of APOE genotyping for late-onset Alzheimer's disease (LOAD) risk estimation: a review of the literature.
Marshe VS, Gorbovskaya I, Kanji S, Kish M, Müller DJ.J Neural Transm (Vienna). 2019 Jan;126(1):65-85.
GWAS-based machine learning approach to predict duloxetine response in major depressive disorder.
Maciukiewicz M, Marshe VS, Hauschild AC, Foster JA, Rotzinger S, Kennedy JL, Kennedy SH, Müller DJ, Geraci J.J Psychiatr Res. 2018 Apr;99:62-68.
The Complex Relationship between Antipsychotic-Induced Weight Gain and Therapeutic Benefits: A Systematic Review and Implications for Treatment.
Raben AT, Marshe VS, Chintoh A, Gorbovskaya I, Müller DJ, Hahn MK.Front Neurosci. 2018 Jan 22;11:741.
C-reactive protein and cardiovascular risk in bipolar disorder patients: A systematic review.
Marshe VS, Pira S, Mantere O, Bosche B, Looper KJ, Herrmann N, Müller DJ, Rej S.Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):442-451.
Genome-wide association studies of placebo and duloxetine response in major depressive disorder.
Maciukiewicz M, Marshe VS, Tiwari AK, Fonseka TM, Freeman N, Kennedy JL, Rotzinger S, Foster JA, Kennedy SH, Müller DJ.Pharmacogenomics J. 2018 May 22;18(3):406-412.
The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain.
Kanji S, Fonseka TM, Marshe VS, Sriretnakumar V, Hahn MK, Müller DJ.Eur Arch Psychiatry Clin Neurosci. 2018 Feb;268(1):3-15.
Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults.
Marshe VS, Maciukiewicz M, Rej S, Tiwari AK, Sibille E, Blumberger DM, Karp JF, Lenze EJ, Reynolds CF 3rd, Kennedy JL, Mulsant BH, Müller DJ.Am J Psychiatry. 2017 May 1;174(5):468-475.
Childhood Abuse History in Depression Predicts Better Response to Antidepressants with Higher Serotonin Transporter Affinity: A Pilot Investigation.
Quilty LC, Marshe V, Lobo DS, Harkness KL, Müller DJ, Bagby RM.Neuropsychobiology. 2016;74(2):78-83.
Molecular mechanisms in lithium-associated renal disease: a systematic review.
Rej S, Pira S, Marshe V, Do A, Elie D, Looper KJ, Herrmann N, Müller DJ.Int Urol Nephrol. 2016 Nov;48(11):1843-1853.
Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder.
Maciukiewicz M, Marshe VS, Tiwari AK, Fonseka TM, Freeman N, Rotzinger S, Foster JA, Kennedy JL, Kennedy SH, Müller DJ.Pharmacogenomics. 2015 Nov;16(17):1919-29.
Genetic Similarities between Compulsive Overeating and Addiction Phenotypes: A Case for "Food Addiction"?.
Carlier N, Marshe VS, Cmorejova J, Davis C, Müller DJ.Curr Psychiatry Rep. 2015 Dec;17(12):96.
Physicians' opinions following pharmacogenetic testing for psychotropic medication.
Walden LM, Brandl EJ, Changasi A, Sturgess JE, Soibel A, Notario JF, Cheema S, Braganza N, Marshe VS, Freeman N, Tiwari AK, Kennedy JL, Müller DJ.Psychiatry Res. 2015 Oct 30;229(3):913-8.