Meet our team.
Leen Magarbeh, MSc
PhD Candidate
Department of Pharmacology and Toxicology | University of Toronto
Leen is a PhD candidate at University of Toronto and working with Dr. Mueller’s research team at CAMH to implement pharmacogenetics for the better treatment of neuropsychiatric disorders. She is formerly a Clinical Pharmacist from Jordan. Leen hold a master’s degree in Clinical Pharmacy, where she conducted pharmacokinetic analysis of plasma probe drugs of CYP450 enzymes and genetic analysis of tissue mRNA. Leen joined CAMH in 2019 and now aims to enhance her knowledge of genetic polymorphisms and their contributions to mental disorders. Currently, she is working on her thesis project which is to investigate selected genetic variants and their association with outcomes to opioids and antidepressant treatment. Leen’s overarching aim is to develop an understanding of how pharmacogenetics can be employed to improve clinical practice guidelines.
Leen’s Projects
Pharmacogenetics of Opioid Overdose
Antidepressant Response in Adults
Selected Publications
ABCB1 Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta-Analysis Including Results from the CAN-BIND-1 Study
Magarbeh L, Hassel C, Choi M, Islam F, Marshe VS, Zai CC, …, Müller DJ. Clin Pharmacol Ther. 2023 Jul;114(1):88-117.
Pharmacogenetics of Lethal Opioid Overdose: Review of Current Evidence and Preliminary Results from a Pilot Study
Magarbeh L, Gorbovskaya I, Wells R, Jhirad R, Le Foll B, Müller DJ. J Pers Med. 2023 May 30;13(6):918.
Reviewing pharmacogenetics to advance precision medicine for opioids
Magarbeh L, Gorbovskaya I, Le Foll B, Jhirad R, Müller DJ. Biomed Pharmacother. 2021 Oct;142:112060.
Image credit: Freepik